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Despite the visual appearance of a funnel plot, the small number of included studies significantly restricts the ability to rule out publication bias definitively, and the implementation of other statistical tests for asymmetry is underpowered with few studies and unreliable results
Mechanistically, oxidative stress activates p16-pRb effector pathway which is thought to play a vital role in SIPS mediation 11
Medically Reviewed by a UK Superintendent Pharmacist This content has been medically reviewed by Mohammed Ismail Lakhi (GPhC: 2072815) , Superintendent Pharmacist at The Care Pharmacy
They are usually mild to moderate and tend to reduce over time
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